Molecular Formula | C63H98N18O13S |
Molar Mass | 1347.63 |
Density | 1.42±0.1 g/cm3(Predicted) |
Melting Point | 148 °C |
Water Solubility | Soluble in water, DMSO, and Acetic Acid. |
Solubility | H2O: 1mg/mL |
Appearance | Form powder, color white |
Color | white |
pKa | 13.26±0.46(Predicted) |
Storage Condition | −20°C |
Physical and Chemical Properties | Chemical properties of white freeze-dried powder, easily soluble in water, high-purity aqueous solution is easy to inactivate, adding Tween 80, gelatin, human plasma albumin or bovine gamma globulin can increase its stability; pH is greater than 8 It is unstable and inactivated by pepsin and chymotrypsin; it should be stored in a low pH value, and filled with nitrogen or added with antioxidants to avoid its inactivation. |
Use | Uses for biochemical research, medicine used as vasodilator, nerve tuning agent, can promote saliva secretion, increase capillary permeability, can cause smooth muscle contraction, blood pressure reduction and stimulate the secretion of tissue, it plays a role in the transmission of pain. |
In vitro study | The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells. |
WGK Germany | 3 |
FLUKA BRAND F CODES | 3-10-21 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 0.742 ml | 3.71 ml | 7.42 ml |
5 mM | 0.148 ml | 0.742 ml | 1.484 ml |
10 mM | 0.074 ml | 0.371 ml | 0.742 ml |
5 mM | 0.015 ml | 0.074 ml | 0.148 ml |
solubility | H2O: 1 mg/mL |
biological activity
Substance P (Neurokinin P) is a neuropeptide that acts as a neurotransmitter and neuromodulator in the central nervous system. The endogenous receptor for Substance P is the neurokinin 1 receptor (neurokinin 1 receptor,NK1R).
target
Human Endogenous Metabolite
in vitro study
The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells.
production method
The bovine hypothalamus is used as raw material, homogenized in acetone and hydrochloric acid solution, filtered and extracted with petroleum ether, and refined by column chromatography and paper electrophoresis.